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despite a short plasma half-life (~2 minutes in rodents), ARA-290 crosses the BBB and exerts central neurological effects Neural and cognitive processing Cerit H et al
Additional benefits: Reduces the appearance of fatigue and dark circles
Nrf2, a pivotal transcription factor responsible for maintaining cellular metabolism and redox balance, governs various molecules associated with ferroptosis, including FT light and heavy chains (FTL/FTH1), the system Xc subunit, the catalytic and regulatory subunits of glutamic acid cysteine ligase (GCLC/GCLM), as well as GPX4 [64, 65]
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